GLOBAL MOLECULAR ANALYSIS AND APOE MUTATIONS IN A COHORT OF AUTOSOMAL DOMINANT HYPERCHOLESTEROLEMIA PATIENTS IN FRANCE[S]

Global molecular analysis and APOE mutations in a cohort of autosomal dominant hypercholesterolemia patients in France[S]

Autosomal dominant hypercholesterolemia (ADH) is a human disorder characterized phenotypically by isolated high-cholesterol levels.Mutations in the low density lipoprotein receptor (LDLR), APOB, and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes are well known to be associated with the disease.To characterize the genetic background ass

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Improving the efficacy of ERP-based BCIs using different modalities of covert visuospatial attention and a genetic algorithm-based classifier.

We investigated whether the covert orienting of visuospatial Console Table attention can be effectively used in a brain-computer interface guided by event-related potentials.Three visual interfaces were tested: one interface that activated voluntary orienting of visuospatial attention and two interfaces that elicited automatic orienting of visuospa

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Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

HIV-1 particles assemble and bud from the plasma membrane of infected Fryer Cookware Sets T lymphocytes.Infected macrophages, in contrast, accumulate particles within an apparent intracellular compartment known as the virus-containing compartment or VCC.Many aspects of the formation and function of the VCC remain unclear.Here we demonstrate that VC

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